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puter programming projects is the ego of computer programmers. They are often more interested in developing tour-de-force programs than in doing what is necessary to come up with a well-integrated product. Too often, they are not good team players. To deal with this common problem, Weinberg suggested that project teams should be structured to minimize the ill effects of egos. When we look at the product of an egoless team, the results of a truly collaborative effort, it should be dif cult to determine who produced what portion of the product. The structure of a three-person egoless team is shown in Figure 3.4. Note that there is no obvious leader on the egoless team. Decisions are achieved through consensus, and project tasks often re ect the input of all the team members. For example, in the technical report example, team member A may write a draft of the rst chapter and then turn it over to team member B, who edits and reworks it. After all the chapters are done, team member C may do a nal editing of the report, to make sure that it is well integrated. To the extent that team members collaborate jointly like this, problems of ego will be minimized. The egoless team structure encourages high levels of interactivity and communication among project members. They are continually in touch with each other and make decisions through consensus. If communication is good and team members are working together toward a common goal, problems of systems integration should be low. I have heard many scathing criticisms of the egoless team approach by those who have tried to implement it in their organizations. One

Because the laser reads probes at a certain frequency, the intensity of re ected light can be converted into measures of amount of mRNA/cDNA and stored in a database for further analysis There are two main types of DNA array: microarray and DNA or gene chip, depending on how probes (nucleotide sequences) are put onto the chip Microarrays use presynthesized DNA (about 100 bases) for probing, whereas DNA chips use in situ synthesized oligonucleotide probes (25 bases for Affymetrix gene chips) More recently, types of array are distinguished by the amount of genes that can be measured, since DNA chips allow for increased numbers of probes due to their shorter length (between 30 000 and 4 million probes for DNA chips, as opposed to about 20 000 probes for microarrays) Microarrays generally use spot technology, whereby a robot places spots (roughly 01 m to 0.

they realize that the need for overtime work is a consequence of bad planning, they will resent your requests for help. The solution to this problem is simple at least in theory: plan realistically. Set realistic goals for project staff. Don t put yourself into the position of depending on people you don t have: perfect project staff members who will do whatever is necessary to get the job done. With realistic planning and goal setting, there is less need to have people work overtime, so there is less need to have superdedicated workers on your project. The chief drawback to this solution is that project managers often have little input into the planning process. Plans are often drawn up before a project manager is assigned to the project. When the project manager nds that the plan is woefully optimistic, he or she might try to renegotiate the plan to make it more realistic. Should this approach fail, the project manager can expect to face pressures to get staff to put in overtime hours on the project.

The behavior of the car park system is depicted as a labeled transition system (LTS) in Figure 5.3. The LTS has been generated directly from the modelFigure of 5.2. It clearly shows that a maximum of four arrive actions can be accepted before a depart action must occur.

Summary

5 m) of DNA on a glass slide (the microarray) and each spot is a DNA counterpart to one of the mRNAs to be measured These DNA spots act as probes and are generally between 100 and 200 bases long The advantage of this method is that specialized microarrays can easily be fabricated to search for speci c genes However, given the size of the spots, there are limits on the number of probes that can be put onto one spot of the microarray For this reason, the use of smaller probes is generally preferred, and these are put on the chip using photolithographic techniques adapted from semiconductor technology The probes are built bottom-up and in parallel in the same way that circuits are, so that nucleotides are added to multiple growing chains simultaneously.